Receptor Modulators (SERMs)
SERMs (selective estrogen receptor
modulators) are non-steroidal compounds that do not contain actual estrogen
hormones and are not considered to be hormones. However, these compounds are
capable of binding to estrogen receptors and influencing their activities.
SERMs are called selective because they can have
estrogen-like effects on certain
cells (i.e. turn on the cell estrogen receptor) or they can block the effects
of estrogen on other cells (i.e. turn off the receptor).
In a woman with low estrogen levels, SERMs
can help increase estrogen response by turning on receptors, such as during
menopause whereas in cases of high estrogen levels, SERMs help turn off
estrogen receptors. SERMs support a moderate level of estrogen activity; when
binding to the estrogen receptors, they can inhibit endogenous estrogen when
too much is present, but at the same time, also support estrogen’s many
important functions, especially for the heart, uterus, breast, vagina and
Natural SERMs: Isoflavones, Red Clover and
Isoflavones (from fermented nonGMO soy). In
Premier Estro Complex, we use the preferred form of isoflavones from nonGMO
Asian soy that has been traditionally fermented. The fermentation process
converts glycone forms of isoflavones into the aglycone form which are absorbed much more completely and
quickly, and are the most effective form of the Isoflavone molecule. Soy
isoflavones that have not been fermented are more difficult to digest and do
not offer genistein, a key isoflavone, in its readily available form. After
fermentation, major available isoflavones are genistein, daidzein, and
Both fermented soy isoflavones and red
clover isoflavones can act as SERMs that can support healthy levels of sex
hormone binding globulin (SHBG), which may also support balanced estrogenic
activity since only unbound estrogens can enter target-tissue cells. In addition,
isoflavones have shown an ability to promote production of the good 2-OH
estrogen over the less desirable 16-OH and 4-OH estrogens. The North American Menopause
Society suggests that soy isoflavones can be a natural alternative to
synthetic estrogen therapy for relief of mild menopausal symptoms such as hot
flashes and night sweats. Isoflavones may help offset the drop in estrogen
and regulate its fluctuations that occur at menopause. Isoflavone research
also shows great promise for serious concerns of the breast, prostate, colon,
lung, blood and skin.
play an important role in protecting and maintaining strong, healthy bones.
Evidence shows that genistein and daidzein help conserve bone mass.
Independent studies conducted at the University of Illinois and the
University of Hong Kong concluded that consuming soy isoflavones helps
increase bone mineral content and bone density. Another study at the
University of Texas suggested that isoflavones may also stimulate bone
formation. By preserving bone mass and stimulating bone turnover, researchers
noted the potential role of soy isoflavones in maintaining bone health during
and after menopause.
Red Clover Isoflavones. Research shows that
red clover isoflavones have also been shown to support healthy arterial
function and heart health; promote healthy bone metabolism and help provide
significant relief from common symptoms of menopause such as hot flashes,
occasional mood swings and sleep imbalances.*
Research shows that DIM also helps balance
estrogen metabolism. Over 40 studies on DIM are on file in the National
Library of Medicine database. DIM has proven to be an efficient way to help
increase the ratio of estrogen metabolites in favor of the â€œgoodâ€
estrogen. In addition to
its estrogen balancing effect, DIM helps stimulate progesterone production
and competes with testosterone for protein binding.
This helps to maintain testosterone in its
free form (the most de-sirable form). DIM helps reduce the conversion of
testosterone to estrogen.
Due to the aging process (especially
prevalent when coupled with obesity or regular alcohol use), estrogen
metabolism is reduced. DIM promotes healthy estrogen metabolism and helps to
improve symptoms of menopause or PMS. As little as 0.5mg/kg body weight/day
of DIM has been demonstrated as an effective dose. That means, for a 150 lb
person, only 30 mg/day would be needed. DIM is also very effective when used
in conjunction with other phytoestrogens such as isoflavones.
Resveratrol is a proven bioflavonoid found
in grapes and certain plants (such as giant knot weed). It has been
classified as a SERM based on its ability to bind to estrogen receptors and
act as both an estrogen agonist and antagonist. Resveratrol provides many other
benefits, including cardioprotective properties.(12) Chrysin is a
bioflavonoid that has been shown to inhibit the activity of aromatase, an
enzyme that synthesizes estrogen from androgens.(13) Aromatase is found in
fat cells, including breast tissue; its inhibition may be useful in
inhibiting the cell-proliferative effects of estrogen.
European Rosemary Leaf Concentrate.
Research shows that the herb rosemary
(Rosmarinus officinalis) helps enhance production of 2-OH estrogen (the good estrogen) while inhibiting the production of the bad
estrogen, 16-OH, and in general, enhances estrogen detoxification. In particular,
rosemary concentrate shows in vitro evidence of supporting healthy breast
Chinese, Nonpesticided Royal Jelly.
Royal jelly is one of the world’s most
complete, natural super nutrient concentrates (unfortunately, most sources
are highly pesticided from worker bees working in pesticided fields). Royal
jelly is the main source of food for the queen bee which has a life span up
to 50 times longer than the worker bees. Royal jelly is rich in all of the
essential B vitamins, along with natural vitamins A, C, D, E and K, more than
12 important minerals, 18 amino acids, acetylcholine (a neurotransmitter),
lecithin and many other constituents.
Royal jelly is an effective anti-aging tonic
with a full repertoire of master nutrients necessary to sustain life, promote
longevity and vigor. Its helps to provide a feeling of well being and to
promote youthfulness. Research shows that royal jelly not only promotes
anti-aging and longevity, but also exerts beneficial effects on almost every
body tissue as well as balancing estrogen and overall hormone metabolism. It
is excellent help during pregnancy, PMS or mild menopause symptoms such as
hot flashes, mood swings, night sweats and feeling blue.
Research also supports royal jelly’s role in memory function, liver support (cholesterol),
heart and circulation efficiency, skin beauty and much more.
Central American Nopal Cactus.
The use of Nopal (commonly known as the
prickly pear) dates back to the Aztec period in Mexico (around 900 AD). Nopal
is highly nutritious and contains a unique phytochemical, vitamin and mineral
profile that contributes to its many beneficial effects. Studies show Nopal’s
valuable role in promoting hormone and glandular balance. It benefits the
pancreas and liver, both vitally important in maintaining blood sugar levels,
triglycerides and cholesterol levels within the normal range, by helping to
metabolize fat and fatty acids and eliminating excess bile acids (excess bile
acid is eventually converted into cholesterol).
Nopal pectins, lignans (natural fiber) and
mucilage benefit the digestive and intestinal systems, including
constipation. Nopal also aids in the balancing the nervous system, which
benefits the body’s overall function. Studies have shown that Nopal also
helps improve the function of the immune system.
Nopal’s many bodily effects are due in part
to its abundance of essential nutrients, including polysaccharides, fiber,
bioflavonoids, natural vitamins, including beta-carotene (A), B1, B2, B3, and
C; natural minerals including potassium, calcium, magnesium and iron, and 18
amino acids (8 which are essential) in an easily digestible form.
Other Nutritional Synergists.
Additional synergists and co-factors of this
formula include European Beta-Sitosterol and sterolins (phytosterols) which
appear to act either as weak forms of estrogen stimulators (agonist
receptor-site action - when estrogen levels are declining) or protectors
against higher levels of estrogens by competitive inhibition (antagonist
receptor-site action). The next synergist, unheated, non-irradiated North
Atlantic kelp, supports the thyroid’s regulation of oxygen uptake at the cell
level, which is critical for detoxification of the reproductive organs and
Marine coral mineral concentrate boosts
tissue oxygen levels and cellular oxygen availability to support alkaline pH
levels for best tissue function. Natural-source free-form amino acids (rice
source) which are highly biologically available (over 95% are free form) are
the perfect co-factor/ transporter for the broad spectrum of botanical agents
in this formula. Bromelain and papain are protein-digesting enzymes from
pineapple and papaya fruit, assisting uptake of nutrients and aiding pain
relief, especially during PMS and menopause. A full-spectrum of highly
purified plant enzymes (protease, lipase, amylase, cellulase, invertase,
lactase, maltase) function as critical co-factors and transporters of all the
nutraceutical compounds in this formula.
Serving Size: 1 capsule
Servings Per Container: 60
Proprietary Formula 480mg*
free-form amino acids (rice
source), nopal cactus (pad) (opuntia ficus-indica), beta-sitosterol, royal
jelly concentrate (6%), DIM (diindolylmethane), red clover (blossom) (Trifolium
pra.), isoflavones (fermented concentrate, non-GMO soy source), marine coral
concentrate, chrysin, quercetin,Â rosemary leaf extract (Rosmarinus
off.), kelp (fronds) (Laminaria dig.), bromelain enzymes (from pineapple),
papain enzymes (rome papaya), resveratrol (derived from giant knot weed), noni
(fruit, seed) (morinda cit.), amylase, maltase, apple cider vinegar, protease,
plant-source pepsin, lipase, lactase, invertase, cellulase
vegetable cellulose capsule
*Daily Value Not
Adults or children
(age 4 and up): Take 1 capsule, 3 times daily. For special programs recomended
by your practitioner, up to 12 individual servings may be taken daily (1
serving = 1 capsule).
If you are pregnant or
nursing, please consult your healthcare professional before using this product.
Keep out of the reach of children.